Endocrine Abstracts

The neuropsychological mechanism underlying cognitive impairment in hypothyroidism is poorly understood. It is not known whether cognitive impairment resolves following L-Thyroxine (LT4) replacement. It is also unknown whether similar neuropsychological abnormalities occur in patients with sub-clinical hypothyroidism (SCH). To address these questions, we performed neuropsychological tests in 17 patients with hypothyroidism (age 45±3 years; mean±S.E.M.)...

Memory formation largely depends on normal function of the temporal lobes (particularly the hippocampal complex) and prefrontal cortex. Evidence from animal studies suggests abnormal hippocampal function in hypothyroidism1. We hypothesized that specific defects in hippocampal-dependent memory would be observed in hypothyroid patients. Patients with overt (n=17) and subclinical (n=17) hypothyroidism underwent neuropsychological testing at baseline, 3 an...